Background: To study the clinical behavior of lupus nephritis in children from Southern India, and to report the differences in disease pattern. Objectives: 1. To study histopathological changes and outcome in paediatric lupus nephritis. 2. To study the clinical and immunological spectrum of lupus nephritis. Methodology: Laboratory received renal biopsy specimens with a clinical diagnosis of SLE by ARA criteria over a period of 6 years were included in the study and were classified according to the 1982 WHO Classification and reclassified ISN classification. Results: Of the 16 cases studied, 12 patients were females (75%). ANA was the most frequently positive parameter occurring in 91% of cases. ds- DNA was positive in 9 cases. Anaemia was present in 10 cases (63%). In our study WHO Class IV lupus nephritis was most the common 63% (n=63). Acute renal failure was seen in 18% of paediatric cases and doubling serum creatinine was noted in 20% of paediatric patients. Interpretation and conclusion: The incidence of disease was 3 times more common in females. WHO class IV was the commonest class, seen in 63% of cases. The percentage of patients having doubling serum creatinine was noted in 20% paediatric age group indicating poor renal outcome and prognosis in children.