Lasers, as a source light energy has gained its importance in various applications in the field of medicine. The low power lasers also called as low level lasers are known to bring about a series of changes in the organs at the cellular and subcellular level. These changes collectively bring about various changes like wound healing, tissue regeneration, controlled secretion of cytokines, expression of gene proteins and various other physiological and biochemical actions. This review is intended to understand the physiological actions of lasers and their beneficial effects on musculoskeletal system.