Invasive plant species represent major ecological threats but may also provide valuable medicinal resources. This review aimed to assess the ecological impact, traditional uses, pharmacological activities, and phytochemical composition of three invasive plant species in Benin: Chromolaena odorata, Hyptis suaveolens, and Leucaena leucocephala. A literature review was conduct ed using data from scientific databases and ethnobotanical sources. These plants exhibit diverse biological activities, including antimicrobial, anti-inflammatory, antioxidant, antiparasitic, and cytotoxic effects. These activities are associated with bioactive compounds such as flavonoids, terpenoids, phenolic acids, alkaloids, and essential oils. Despite their ecological harm, they are promising sources of therapeutic agents, highlighting the need for management strategies combining control and medicinal use..