Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation, progressive joint damage, and functional impairment. Despite advances in pharmacological therapy, many patients continue to experience reduced physi cal capacity and persistent disability. This narrative review evaluated the effects of different forms and intensities of physical activity on inflammatory markers and disease progression in individuals with RA, with particular emphasis on high-intensity exer cise. A literature search was conducted using PubMed, Scopus, and Web of Science databases and included studies published between 2015 and 2025 assessing the effects of physical activity on inflammatory markers, disease activity, physical function, and clinical outcomes in adults with RA. The available literature suggests that moderate- to high-intensity physical activity, in cluding aerobic, resistance, and interval training, may be associated with reductions in inflammatory markers such as C-reactive protein, interleukin-6, and tumor necrosis factor alpha. High-intensity interval training has been reported to improve cardiorespi ratory fitness and metabolic function without exacerbating disease activity when appropriately supervised. Low-impact modali ties, including yoga and rehabilitation-based exercise, have also been associated with symptomatic and functional benefits in several studies. Transient inflammatory responses may occur following acute intense exercise, but these do not appear to result in sustained disease worsening. Overall, physical activity may provide important anti-inflammatory and functional benefits for individuals with RA when tailored to disease activity and individual capacity, and should be considered an important component of comprehensive RA management. Abbreviations: CRP – C-reactive protein; IL-6 – interleukin-6; TNF-α – tumor necrosis factor alpha; HIIT – high-intensity interval training; VO2 max – maximal oxygen uptake.