Introduction: Venous thrombosis is not an uncommon entity in medicine wards. Clinically, in majority of patients of venous thrombosis one or the other risk factor can be identified. Radiological investigations like-Duplex sonography, Coronary Transhepatic Pulmonary Angiography(CTPA) and Magnetic Resonance Imaging (MRI) venography have revolutionized the diagnosis of these disorders. There is an urgent need and scope to identify factors contributing to thrombophilia. Method: A prospective observational study over a period of 7 months including all the patients admitted in one unit of medicine. Results: Overall prevalence of venous thrombosis was 4.18% (26 out of 622 patients). The mean age of patients was 40.7 __ampersandsignplusmn; 16.2 years. Patients were divided into two groups. Group 1 (19 patients) consisting of patients with venous thrombosis (11 patients) and pulmonary thromboembolism (8 patients). Whereas group 2 (7 patients) had patients with cortical venous thrombosis (CVT). CVT and Deep Vein Thrombosis (DVT) were predominantly seen in females while pulmonary embolism was common in males. While in Group 1, Dyspnoea and pedal oedema were the commonest features. In group 2, headache followed by focal neurological deficit was common. All the cases were confirmed by necessary radiological investigations. All patients received enoxaparin. Thrombololysis was additionally given to 5 patients of group 1.11 (42%) patients had one or more risk factors. Overall mortality was 26%. Conclusion: Significant number of patients of venous thrombosis had one or the other risk factors. In this highly selective group wherever the tests were done, they demonstrated presence of thrombophilic state. It reinforces the belief that thrombophilias are prevalent in our population.