IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy4888 https://doi.org/10.31782/IJCRR.2026.18102Healthcare Synthesis, Spectral Analysis and Biological Evaluation of a Novel Schiff Base [N-(2-hydroxy 1-naphthylmethylene)-5-acetyl-2-amino-4 methylthiazole] and its Complex       SolankyInduMalikSumanSinghArchanaDadoriaAnjul15012026)510This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

Introduction: Schiff base ligands containing Thiazole and naphthalene groups are important in coordination chemistry and medicinal research due to their strong metal binding ability and biological potential. Aim/Objectives: To synthesize a novel Schiff base ligand and its Fe (III) complex and evaluate their antibacterial activity. Methods: The ligand was prepared by condensation of 2-hydroxy-1-naphthaldehyde with 5-acetyl-2-amino-4-methylthiazole. The Fe (III) complex was synthesized in ethanolic medium under controlled pH. Characterization was carried out using elemental analysis, UV–Visible, FT-IR, mass, magnetic and XRD studies. Antibacterial activity was tested by agar well diffusion method. Results: Spectral data confirmed tridentate coordination through azomethine nitrogen, phenolic oxygen and Thiazole nitrogen. Magnetic studies supported an octahedral geometry. The metal complex showed better antibacterial activity than the free ligand. Conclusion: The Schiff base forms a stable octahedral Fe (III) complex with enhanced antibacterial activity, indicating its poten tial for further pharmaceutical applications.

Schiff base ligand Fe (III) complex Tridentate coordination Spectroscopic analysis Octahedral geometry Antibacterial activity