Fruits have a significant role in the diet of human. Wastes are the unconsumed or unused fractions of a fruit and vegetables due to their morphological characteristics. Many fruits as well as vegetables produce up to 25- 30% of waste. The lack of proper infra structure and methods are responsible for massive losses of important food components, by-products and residues. This review focuses on presence of bioactive compounds of some fruit by-products and possible utilization in various industries. Studies from 1986 to 2018 were reviewed from books, research paper and review articles. Currently, thousands of bioactive molecules have been isolated as well as identified from different fruit waste. The horticultural by-products are good sources of phenolic com pounds, pigments, dietary fibers, organic acids, sugar derivatives, minerals and other constituents. These bioactive molecules have beneficial properties like cardioprotective, antibacterial, antimutagenic, antitumor, antiviral properties. Fruit and vegetable wastes can be utilized by isolation potential bioactive molecules and can be utilized in pharmaceutical, food, cosmetics indus tries. Research should be encouraged to explore the therapeutic and toxic effects, pharmacokinetics of bioactive molecules.