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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">4877</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url">https://doi.org/10.31782/IJCRR.2025.172101</article-id><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>&#13;
	Comparison between Naltrexone-Bupropion and Psychological Treatment in Binge Eating Disorder&#13;
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</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Stolarczyk</surname><given-names>Dominika</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sitko</surname><given-names>Maria</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bak</surname><given-names>Aleksandra</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mojzesz</surname><given-names>Piotr</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bieniasz</surname><given-names>Anna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zdzieblo</surname><given-names>Anna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zdzieblo</surname><given-names>Katarzyna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Piwowar</surname><given-names>Michalina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Biernacki</surname><given-names>Igor</given-names></name></contrib><contrib contrib-type="author"><name><surname>Agopsowicz</surname><given-names>Katarzyna</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>13</day><month>11</month><year>2025</year></pub-date><volume>1)</volume><issue/><fpage>1</fpage><lpage>6</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>&#13;
	Binge eating disorder (BED) belongs to an eating disorder that occurs in both adult and adolescent populations. The disorder is associated with physical disorders such as obesity. It also touches the psychological sphere including impulse control disor der. Recent years have been associated with the development of new treatment strategies for this disorder. Safety-appropriate pharmacological treatments are still being sought. Substances such as lisdexamfetamine or topiramate initially combined to treat obesity-related BED have proved ineffective or unsafe in this indication. Recent studies report the possible efficacy of combining naltrexone with bupropion in the treatment of BED. The combination of these substances affects the genetic mechanisms that promote the production of leptin, the satiety hormone. Psychological treatments such as cognitive behavioral therapy (CBT), its variant dialectical behavior therapy (DBT), interpersonal therapy (IPT) or behavioral weight loss therapy (BWL) still have a well-established and fundamental role in the treatment of eating disorders, including BED. This systematic review included meta analyses on the treatment of BED between 2004 and 2025. Only double-blind, placebo-controlled RCTs were included in the study. Databases such as PubMed, PsycINFO, and Google Scholar were searched. Most studies showed no advantage of NB over placebo in reducing the frequency of binge eating episodes and BED symptoms. The main benefit of NB in the treatment of BED is weight loss. Preliminary results showed that combining a pharmacological approach (NB) with a psychological approach (CBT) is most effective in reducing BED symptoms.&#13;
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</p></abstract><kwd-group><kwd>Binge eating disorder</kwd><kwd> Naltrexone</kwd><kwd> Bupropion</kwd><kwd> Cognitive behavioral therapy</kwd><kwd> Psychological treatment</kwd><kwd> Obesity</kwd><kwd> Behavioral weight loss</kwd></kwd-group></article-meta></front></article>
