Introduction: Cancer is a significant global public health concern that demands immediate attention as it affects populations worldwide. Among cancers affecting women, cervical cancer stands out as the fourth most common. Remarkably, it is worth noting that around 90% of these deaths occurred in countries with low or middle incomes. These countries face challenges such as limited access to public health services and the inadequate implementation of screening and treatment measures for this disease. In Saudi Arabia, a country with a population of 10.7 million, women aged 15 years and older are at risk of developing cervical cancer. Aim/Objectives: In this present study, the prevalence of abnormal Pap smears and their quality metrics at the Prince Sultan Military Medical City were analyzed. Additionally, the study sought to shade light on the evolutionary trend of this clinical technique for cervical screening in Riyadh and probably serve as cohort finding for the Saudi population. Methodology: A retrospective analysis was carried out using the medical result sheets from medical analyses conducted between 2010 and 2021, at the Prince Sultan Military Medical City in Saudi Arabia. The focus was on smears, cervical cancer, Human papillomavirus (HPV), and atypical glandular cells. Results: The study examined Pap smear data, including both conventional and liquid-based cytology (LBC), for a total of 27,319 collected between 2010 and 2021.Out of the 27,319 pap smears, 2.93% (801) were classified as abnormal, with 3.18% (869) been considered unsatisfactory (UNSAT) for diagnostic. Conclusion: We recorded 1.72 ratio for atypical squamous cell and squamous intraepithelial cell, as with 0.98% prevalence in abnormal pap smears. We observed a fluctuating, relatively stable and a decreasing frequency of atypical glandular cells, respectively before the onset, during, and after the Covid-19 pandemic. We believe these variations in frequencies are due to different factors.