Aims: The present study was done to assess the usefulness of the cord blood bilirubin estimation as a predictor of subsequent neonatal hyperbilirubinemia in a healthy term infants who require phototherapy. Setting and Design: A prospective cohort study was conducted at tertiary care centre. 100 term newborn delivered by LSCS was included in this study. Methods and Materials: 5ml of blood was collected from umbilical cord during delivery. It was used for estimation for conjugated, unconjugated, total serum bilirubin levels and blood group. All enrolled babies were followed up for 5 days and clinically assessed for jaundice according to Kramer dermal scale. In these babies, bilirubin estimation was done on samples collected at birth (cord blood), at 72 hrs. of life (3rd day), at 120 hrs. of life (5th day). Results: Cord blood bilirubin level of more than 2.15mg/dl has a sensitivity of 65% and specificity of 65% % in prediction of neonatal hyperbilirubinemia. Babies having serum cord bilirubin level of __ampersandsigngt;2.15mg/dl can be followed up in the hospital for 5 days, the time of peak neonatal hyperbilirubinemia to prevent the babies discharged early and later readmission for neonatal hyperbilirubinemia. Conclusion: It is recommended to have cord blood bilirubin estimation of all healthy term babies delivered in an institution to prevent the dangerous consequences of neonatal hyperbilirubinemia like Kernicterus6