Due to number of patients with depression constantly growing, new methods of treating and improving their well-being are being looked for. Depression has remained among the top diseases in terms of prevalence worldwide for years, and part of the patient group is resistant to drug treatment. Research in the area of improving the well-being of patients struggling with depression and facilitating their treatment process, such as through lifestyle changes, continues to expand. In 2006, the first publication suggesting a positive effect of botulinum toxin type A in patients suffering from depression appeared, and consistently in the following years more and more scientific papers appeared. Botulinum toxin treatments for the face are very popular; it is a drug registered for many medical indications. So what information do we have on this subject at this point? Could depression potentially become one of the indications for botulinum toxin use in the future?