Introduction: Fungal infections at different sites are showing increasing incidence in both healthy and Immunocompromised individuals. Among the fungal infections, Aspergillus and Mucormycosis are the common infections, involving maxillary sinus, oral cavity, lung followed by each case of maduramycosis of foot and mucormycosis of forearm in this study. Aims: To study the clinical and pathological profile of fungal infections at various sites. Settings and Design: A Retrospective observational study conducted in Department of Pathology from Jan 2011- Dec 2012, VMKV medical college, Salem. Material and Methods: Seventeen cases were analyzed in this study with respect to clinical history, physical examination and neuroimaging [computed tomography (CT) or magnetic resonance imaging (MRI)] wherever necessary. Operated specimens were received in 10% formalin for histopathological examination. Results: Male:female ratio was 11:6. Mean age of 49 years. The common clinical presentations were nasal discharge followed by oral ulcer and foot ulcer. Commonest site of lesion was nasal cavity (59%). Mucormycosis was the commonest fungus. Conclusions: Early diagnosis and prompt treatment can reduce the mortality and morbidity of this lethal fungal infection. __ampersandsignnbsp; __ampersandsignnbsp; __ampersandsignnbsp; __ampersandsignnbsp; __ampersandsignnbsp; __ampersandsignnbsp; __ampersandsignnbsp;