Introduction: Living with HIV/AIDS can significantly impact a person’s mental health, posing various challenges that extend beyond the physical aspects of the disease. The intersection of HIV/AIDS and mental health presents a complex landscape influenced by a range of factors, including stigma, social isolation, psychological distress, and the implications of a chronic illness. Upon receiving an HIV/AIDS diagnosis, individuals often experience a whirlwind of emotions, such as fear, anxiety, shock, and uncertainty about the future. The stigma surrounding HIV/AIDS can exacerbate these feelings, leading to self-isolation, shame, and a reluctance to seek support or disclose their status due to fear of discrimination or rejection. Aim/Objectives: Impact of gender, age and stages of HIV on mental health among persons living with HIV/AIDS in Rayalaseema region of Andhra Pradesh state. To assess the impact of gender, age and stages of HIV on mental health among persons living with HIV/AIDS. Sample: The subjects of the present investigation are drawn HIV/AIDS persons in ART and ICTC centers in Rayalaseema Region of Andhra Pradesh State of India. Tool: Mental health status inventory designed by Jagadish and Srivastava (1983) was used. Design: There are three independent variables in the investigation and each variable is further classified into two, a 2 × 3 × 4 factorial design was employed. Results: Mean, SD and ANOVA (Analysis of Variance) were calculated. Discussion: Males are good mental health than females. Conclusion: Subjects of 26-35 years are good mental health than the subjects of 46-55 years. Subjects with Primary Infection are good mental health than subjects with Opportunistic Infections/AIDS.