Study: To study clinical profile CD4 count and outcome in children with HIV/AIDS below 12 years of age. Aims and Objective: To study, in children with HIV/AIDS Clinical profile, CD4 count and Out-come. Material and Methods: The study was carried out in ART OPD and pediatric ward over one year duration. All children who were HIV reactive below 12 years were enrolled. Detail history examination and investigation done clinical profile, symtomatology, staging CD4 count and outcome studied in these cases. Result: Males (79%) are affected more than females, while common age of presentation was 8.2yrs. Majority of patients were in WHO staging of Stage III (33.6%) and Stage IV (29.6%), most common symptom was weight loss in 50 cases and commonest sign was generalized lymphadenopathy in 57 cases. Tuberculosis was the most common opportunistic infection in 18.4%. Baseline CD4 count was __ampersandsignlt;15 % in 52% cases. Out of 125 cases, 75 improved, 15 deteriorated, 30 lost follow up and 5 expired. Conclusion: In these studied patients of HIV infection males are affected more and common age of presentation was 8.2 years. Most common symptom was weight loss and tuberculosis was the most common opportunistic infection. Majority patients were in stage III and stage IV. ART has improved these patients and is the prime central management for these cases.