Introduction: Numerous studies have shown that curcumin possesses multifunctional pharmacological properties inducing apoptosis in a variety of tumor cells. Aim/Objectve: It is very significant work to investigate the quantitative structure activity relationship (QSAR) and inhibition mechanisms of these curcumin-related compounds. Method: QSAR studies of curcumin-amino acid bioconjugates have been carried out for their chemotherapeutic or anticancer activity against skin cancer cells. Based on molecular descriptor calculated by DRAGON software for QSAR, some key structural factors responsible for chemotherapeutic activity of these compounds were revealed. Results: The results have provided some useful theoretical references for understanding the mechanism of action, designing new curcumin-related compounds with chemotherapeutic activity and were predicted their activities prior to synthesis. Conclusion: The curcumin - glutamoyl derivative appeared to be the most effective compound when tested for antiproliferative potential.