Introduction: Methicillin-resistant staphylococcus aureus, a multi drug resistant bacterium is responsible for a broad spectrum of human and animal diseases ranging from skin infections to severe disorders as pneumonia, endocarditis and septicemia causing morbidity and mortality worldwide. This has led to growing interest in exploring novel methods to treat increasing drug resistance. Aim/Objectives: Aim of our study was to determine the anti-MRSA activity of silver and gold nanoparticles alone, also combination of amoxicillin and silver nanoparticles combination. Materials and Methods: The antimicrobial activity of silver and gold nanoparticles was evaluated using Disc diffusion method and amoxicillin in combination with silver nanoparticles by determining the colony forming units. Results: Silver nanoparticles showed anti-MRSA activity whereas gold nanoparticles, amoxicillin and silver nanoparticles combination showed no activity against MRSA clinical isolates.