Introduction: Polycystic Ovary Syndrome (PCOS) is a major endocrine disorder in women affecting their Health-related Quality of Life (HRQOL) and their mental well-being as well. Aim and Objective: The current study aimed to access the Quality of life of women diagnosed with Polycystic Ovary Syndrome. Methodology: A prospective, cross sectional, questionnaire based HRQOL study was conducted among PCOS women aged between 18 - 45. Of 262 responses, 253 responses who were willing to participate in the study were included. The Polycystic Ovary Syndrome Questionnaire (PCOSQ) was used to assess the HRQOL among PCOS women. Results: Overall 57.71% of the participants were aged between 18 to 25 years of age. Among the five major domain, highest score was observed in Body hair (4.35±1.4) and the lowest score was observed in Body weight (3.43±1.21). The comparison of the mean score of PCOSQ among age groups, significant difference was observed among Body weight (p=0.01), Infertility (p=0.001) and body hair (0.04) in 18 – 25 years age group. There is a significant difference in HRQOL among marital status of women in terms of Infertility (p=0.002), Body weight (p=0.04) and Emotion (p=0.02). HRQOL among the socioeconomic status showed that there is a significant difference in Menstrual issues (p=0.04), infertility (p=0.047), emotional (0.04) PCOSQ domain. Conclusion: HRQOL is significantly reduced in PCOS women. Currents study data suggested that infertility, emotions, and body weight all had a significant impact on the HRQOL of women with PCOS. Overall, PCOS reduces the QOL, which needs to be assessed periodically.