Introduction: According to World Health Organization worldwide estimates 60-80 million couples suffer from infertility. Infertility or the inability of a female to conceive despite 12 months or more of unprotected coital exposure can be due to several factors including uterine anomalies, tubal anomalies, and hormonal imbalance among others. Aims and Objectives: The scope of this study includes impact of Uterine Anomalies on primary infertility. Materials and Methods: The study includes evaluation and investigation of 100 cases of infertile females and women with bad obstetric history over a period of 3 years from 2007 to 2009 in Gandhi Hospital, Secunderabad, Telangana. A detailed history for every complaint in all the cases was taken by the in charge gynaecologist. Results: In the present study the bicornuate uterus predominates with 40% (4 cases out of 100). Septate uterus and uterus didelphys were observed in 2 cases each (20%), whereas arcuate uterus and unicornuate uterus were observed in 1 case each (10%). Conclusion: It is pertinent to note that, a fairly high incidence of bicornuate uterus and uterus didelphys with poor reproductive outcome in the present study provokes a challenge in terms of management protocol on account of its morbidity and demands a meticulous antenatal surveillance. Considering the low socioeconomic and rural background in most of the cases in this study, it is worthwhile to investigate whether nutritional and environmental factors play a role in the genesis of the reproductive system.