Introduction: Thalassemia can be classified into alpha and beta depending on the reduced synthesis of alpha or beta chains present in hemoglobin (Hb),1 that results in reduced hemoglobin in body than normal. Aims: Aims at signifing the importance of timely dental treatment in Beta thalassemia patients. Case Report: Here we present a known case of beta thalassemia minor requiring a full mouth rehabilitation treatment performed dental chair-side. Discussion: Thalassemia minor patients inherit only a single beta-globin mutation and have a mild anemia.2 The evaluated predominance of β-thalassemia minor (carriers) in India is 3-8%, which transforms to 35-45 million carriers in 1.3 billion diverse population with culturally and linguistically multi-ethnic people.3. Conclusion: Several ethnic groups have a much higher prevalence of 4–17%.4 The Beta thalassemia minor cases usually go undetected and are often observed in tests for dental treatment or post-dental treatment.