IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy467HealthcareNATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1 POLYMORPHISM SUSCEPTIBILITY TO MULTI DRUG RESISTANCE TUBERCULOSIS IN SOUTH INDIAN POPULATION: A CASE __ampersandsignndash;CONTROL STUDY M.Rooth VasanthaSudhakarG.SrideviS.21082015)3033This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

Aim: To know the association of NRAMP1 gene polymorphisms in MDR-TB Patients. Methodology: Studies on NRAMP1 (Natural Resistance Associated Macrophage Protein1 or SLC11A1 revealed its function on macrophage activation and its association with infectious diseases. A case-control study was carried out to find the association of NRAMP1 gene with MDR-TB belonging to Visakhapatnam district of Andhra Pradesh, India. Genetic polymorphisms of NRAMP1 gene 3__ampersandsignrsquo;UTR and 274 CT were analysed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Significant statistical difference in the 3__ampersandsignrsquo;UTR polymorphism between MDR-TB patients and healthy controls was observed. (P=0.001, OR=0.691,95%CI=0.077-6.208). But no significant association was found between the disease and 274 CT polymorphism (P__ampersandsigngt;0.05). Conclusion: Significant association of MDR-TB with 3__ampersandsignrsquo;UTR polymorphism of NRAMP1 gene was identified, while no significant association was observed in 274CT polymorphism of NRAMP1 gene. Further study with large sample size is required to confirm the above results.

NRAMP1 3’UTR 274CT MDR-TB