Introduction: Hand hygiene is crucial in the healthcare industry, since it helps reduce the spread of germs between patients and healthcare personnel. Our primary aim was to identify the obstacles that nursing students face when attempting to maintain proper hand hygiene. Aims: The goal of this research was to identify the obstacles that nursing students face when attempting to practise proper hand hygiene. Methods and Materials: Purposive sampling was utilised for this descriptive study of 196 undergraduates in their first and second years of basic BSc; the students themselves created and administered the study’s structured questionnaire, which was then expert-validated and approved for use. Researchers informed participants of the study’s goals before collecting any data. The levels of knowledge (bad, good, and outstanding) were utilised. The data analysis was carried out in accordance with the aims of the study. Result: According to the study’s findings, the majority of students (87%) are under the age of 19, the majority of female students (161) are between the ages of 81 and 19, the majority of students (51%) have completed at least 12 years of schooling, and the majority (96%) of students who are not married. 53.57 percent of pupils had demonstrated moderate difficulties in clinical procedures, according to the descriptive study. A total of 27.4% of the population planted their barriers while washing their hands. Only 19.39% of people ever do not feel the need to wash their hands. Conclusion: We conclude that educational and motivational intervention with students, coupled with seminars on the necessity of hand washing during clinical practises, is necessary to prevent the clinical hospital acquired infection.