Introduction: Pregnancy is a state of metabolic stress associated with high lipid levels; the highest concentration observed during third trimester. The imbalance in the amount of lipidshas been related to maternal-perinatal pathologies such as preeclampsia (PE), gestational diabetes mellitus (GDM) and preterm birth. Aim/Objectives: Our study was aimed at studying the association of serum lipid profile during second trimester with the various adverse pregnancy outcomes. Methods: A cohort of 150 antenatal mothers were recruited and were evaluated for serum lipid profile during the second trimester. They were followed up till delivery and maternal and neonatal outcome, were recorded. Conclusion: It was concluded that there were direct implications of dyslipidemia on maternal and perinatal outcomes. Increase in maternal TG, TC, LDL and VLDL concentrations were the most important changes affecting maternal outcomes and had significant association with GDM, PE and PTB. HDL did not have any association with any adverse maternal or neonatal outcome.