Introduction: The difficulty of breathing due to nasal blockage is a common grievance in ENT-based practice. Nearly eighty percent of the people have some grade of deviated nasal septum (DNS). Septoplasty is the choice for the correction of DNS. Septal cartilage provides structural support to the dorsum of the nose; it may have also deviated during the birth of a baby. The acquired septal deviation may occur after trauma in childhood or adult life. Treatment of DNS is septoplasty and it is widely used. Aim/Objectives: To compare the mean time to the first request for analgesic demand postoperatively in cases of septoplasty by using intravenous paracetamol pre-emptive versus intraoperative. Methodology: A total of sixty-four patients were included in this study with both genders who had deflected nasal septum. Age ranges between 18 to 40 years. We divided the patients into two groups randomly. Groups A, and Group B i.e., pre-emptive and Intraoperative paracetamol groups. A total of thirty-two patients were in each group. All patients underwent septoplasty under general anesthesia. In group A, patients received paracetamol 1gm by intravenous route fifteen minutes before the induction of general anesthesia while in Group B, patients received 1gm I/V paracetamol 1gm. at the end of surgery before extubating the endotracheal tube. Postoperatively, patients were shifted to the post-anesthesia care unit (PACU) for standard monitoring and observation. Time for the first analgesic demand in minutes was noted by the on-duty resident doctor. Results: The mean age of patients in the pre-emptive paracetamol group was 29.50 __ampersandsignplusmn; 9.50 years and the mean age of the patients in the intraoperative paracetamol group was 30.50 __ampersandsignplusmn; 9.50 years and the p-value was 0.819. The mean time for the first analgesic demand in the pre-emptive paracetamol group was 180.97 __ampersandsignplusmn; 14.25 minutes and the meantime for the first analgesic demand in the intraoperative paracetamol group was 170.89 __ampersandsignplusmn; 14.04 minutes (p-value 0.001). Conclusion: Substantial difference was noted in the meantime to the request for the first analgesic demand postoperatively in the septoplasty cases between pre-emptive paracetamol versus intraoperative paracetamol. The mean time consumed for the first analgesia is lengthy while using pre-emptive intravenous paracetamol as compared to intraoperative paracetamol.