Introduction: The uses of Lepidium sativum seed mucilage (LSSM) as a disintegrant in various pharmaceutical formulations were already discussed. Researchers claimed that the different functional properties of the seed mucilage of Lepidium sativum enable it to use as a natural disintegrant. Furthermore, scientific research on the disintegrant activity of the LSSM has revealed that it could be effectively used as an alternative to synthetic disintegrants. However, certain factors restrict its use as a disintegrant on the large scale. Aim: In the current scientific discussion, we technically analyzed the prospective obstacles that limit the use of Lepidium sativum seed mucilage as a natural disintegrant in pharmaceuticals. Discussion: In the present discussion, the real case scenario of the functional use of LSSM as a disintegrant on the large scale in different pharmaceutical formulations was summarized. Diligence effort was given to evaluate the different factors associated with the isolation process as well as the intrinsic functional properties that restrict its use as a disintegrant. Conclusion: In conclusion, we opined that Lepidium sativum seed mucilage (LSSM) can be used as a disintegrant. However, before its use in the pharmaceutical industry on a commercial scale, a lot of research and development must be done.