Ayurveda is an ancient system of healthcare and a way of life that deals with the prevention and promotion of health and treatment of various acute and chronic difficult-to-treat ailments. The knowledge of Ayurveda is precious but it somehow lost its charm in past due to lack of utilization of its propositions clinically. The relevance of AYUSH is becoming more important in the present scenario because of changes in the disease spectrum and notion that prevention of disease could be equally (and at times only) significant thing to achieve. This has bought new scientific insights to the basic theories of Ayurveda. Recent declaration of the establishment of WHO Global Centre for Traditional Medicine (GCTM) in Jamnagar with the acquiescence of Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization and honorable Prime Minister Shri Narendra Modi, will definitely add credit to the present account. Also, it will serve the original essence of Ayurveda by taking it to reach of every mankind with sufficient and reliable services. This short communication is just an attempt to provide a brief map to the journey of the uprising of indigenous systems of medicine with the establishment of Ministry of AYUSH.