Introduction: Aim/Objective: To compare first analgesic demand in minutes after obstetrics __ampersandsignamp; gynecological operative procedures between pre-emptive versus intra-operative groups by using intravenous paracetamol. Study Design: A cross-sectional study Place and Duration: Department of Obstetrics __ampersandsignamp; Gynecology, Social Security Landhi Hospital, Karachi, and the total duration was 18 months i.e. 1st January 2019 till 30th June 2020. Methodology: Total number of patients were 120 and the age range was between 22- 50 years. Randomly patients were divided into two equal groups, group 1 and group 2. A total of 60 patients were in each group. In group 1, 1gram intravenous paracetamol was given 15 minutes before anesthesia either spinal or general. While in group 2, the same dose of intravenous paracetamol was given during operative procedures. Mean time for the first analgesic demand was observed and recorded. Result: Mean age of the patients was 40.53 __ampersandsignplusmn; 9.10 years in group 1 and 39.25 + 10.70 years in group 2 and the p-value was 0.820. The mean weight of patients was 62.25 __ampersandsignplusmn; 9.24 kg in group 1 and in group 2, it was 57.21 __ampersandsignplusmn; 11.48 kg and the p-value was 0.689. American society of anesthesiology-I status was found in 56 patients and American society of anesthesiology-II status was found in 64 patients. The mean time required for the first analgesic demand in group 1 was 188.75 __ampersandsignplusmn; 7.75 minutes and in group 2, it was 158.90 __ampersandsignplusmn; 12.50 minutes and the p-value was found __ampersandsignlt;0.001 (significant) Conclusion: Time required for the first analgesic demand is prolonged (188.75 __ampersandsignplusmn; 7.75 minutes) in the pre-emptive paracetamol group as compared with the intra-operative group (158.90 __ampersandsignplusmn; 12.50 minutes).