Introduction: The main purpose of endodontic treatment is to retain the involved teeth in the oral cavity for as long as possible by the prevention and elimination of infection in the root canal system. Irrigation of the root canal after instrumentation is a fundamental component of endodontic treatment success. It is mainly aimed to achieve debridement, smear layer removal, and disinfection of the entire root canal system. Recently, Photon Induced Photoacoustic Streaming (PIPS), which is an activation technique based on the using of Er:YAG (2.940nm) laser equipped with PIPS tip at sub-ablative energy levels, has been used to achieve this goal. Objective: Evaluate the ability of PIPS technique in removing smear layer and remnants. Material and Method: Review and summarize studies evaluated the effect of PIPS in root canal treatment. Results: Several in-vitro studies has been evaluated the evidence to support the benefit of PIPS technique over the traditional and other laser agitation techniques as an efficient method regarding removal of smear layer, remnants disinfection of root canal system and its benefits in other procedures. Conclusion: Photon-induced photoacoustic streaming in in-vitro studies seems to show better smear layer removal at coronal and middle thirds of root canal but not at the apical third, it has no superior effects compared with the other activation technique of endodontic solution.