Introduction: Among South-East Asia region, India shares two-thirds of the burden of malaria. In Tamil Nadu, Chennai is endemic for malaria in the past few decades. Health education and awareness of malaria among the community are indispensable. The present study was undertaken to create awareness and to assess the effectiveness of the awareness on malaria among Arts and Science college students in Chennai. Materials and Methods: This was questionnaire based cross sectional study conducted among college students in Chennai. Each student was given a pair of pre tested semi-structured questionnaire and was instructed to fill the Questionnaire A before and Questionnaire B at the end of the awareness program anonymously. Statistical analysis was done using McNemer__ampersandsignrsquo;s test. Results: Age of students who participated in the study (501) ranged from 16 to 37 years. With regard to malaria transmitted by blood transfusion, Red Blood cells being commonly affected, availability of vaccines and eligibility for blood donation, the response rose significantly to 87%, 91%, 63% and 91% respectively after the awareness programme (p=0.000). Conclusion: By educating college students about malaria and its preventive aspects and its recent developments, it is possible to make them as ambassadors to create awareness and spread knowledge among their families, friends, and relatives and in the community. This helps in achieving the main objective of malaria control in reducing malaria cases and deaths by providing access to preventive methods, diagnostic testing and treatment to the entire population at risk.