Introduction: Treatment of wounds is a crucial process that requires an event of cell migration to control blood perfusion and repair in a short time period. The series of cell migration involves debris removal, infection control, reducing inflammation, formation of granulation tissue. Aim: To examine the effectiveness of vacuum-assisted closure therapy for open musculoskeletal injuries. Methodology: All the patients underwent the standard radiological assessment. We performed a routine hematological investigation. We gently placed the open-pore foam (35 PPI density and 33 mm thick) dressing into the cavity of the wound. We used 400__ampersandsignndash;600 microns size polyurethane open-pore foam because these foams are effective at transmitting mechanical forces across the wound also assist wound healing by applying pressure on the entire wound. The drape was used to seal the wound site. Study design: A cross-sectional study. Place and Duration: This study was conducted at Muhammad Medical College and Hospital Mirpurkhas, PHQ Hospital Gilgit, Fauji Foundation Hospital, Rawalpindi Pakistan from June 2020 to June 2021. Results: For this study, we recruited 30 patients with a mean age of 39 __ampersandsignplusmn; 18 years. All the selected patients had acute trauma. We observed 13.33% cases with decreased wound size greater than 25mm over 8 days however no significant difference was found between 0 to 8 days. The overall mean difference of wound size was reported as 13.24 __ampersandsignplusmn; 8.48 with a significant p-value of 0.0001 which depicts a significant shrink in wound size over time. Regarding bacterial growth, we observed that at day 0 all patients reported bacterial growth which reduces to 40% cases at day 8. Conclusion: Outcomes of our study revealed that vacuum-assisted closure therapy is an effective method for managing open musculoskeletal injuries. Sub atmospheric pressure reduces blood perfusion, increases the formation of granulation tissue, and also minimizes tissue bacterial growth.