Introduction: Mucositis is an inflammatory illness that affects the mouth__ampersandsignrsquo;s mucous membranes.It could be the result of an infection or an indication of something more serious. Oncology nurses play a crucial role in improving patient outcomes related to oral mucositis. Honey has long been used to prevent and cure oral mucositis. Aim: The aim of the study to assess the effectiveness of topical application of pure honey on radiation-induced mucositis in cancer patients undergoing radiotherapy. Material and Methods: The style adopted for the study is true experimental design with two group pre-tests with the experimental analysis approach was wont to judge the effectiveness of topical applications of pure honey on radiation-evoked mucositis patients. This study was conducted in GSL Cancer hospital Rajahmundry. The sample size consisted of sixty patients suffering type oral mucositis patients who are admitted in GSL cancer hospital at Rajahmundry. Sample random sampling technique was used for the choice of sample. knowledge was collected by mistreatment WHO mucositis assessment scales __ampersandsignamp; one observation checklist to assess the grade of radiation-induced mucositis in patients. Modified WHO oral mucositis assessment scale. Data were analysed using descriptive and inferential statistics. Result: The results of this study showed that, oral mucositis score of experimental and control groups mean were 9.73 and1.7 respectively. The standard deviation was 0.927 and 14.55 respectively. Hence calculated t__ampersandsignrsquo; value 2.66 is greater than tabulated __ampersandsignlsquo;t__ampersandsignrsquo; value 2, __ampersandsignlsquo;p__ampersandsignrsquo; value is 0.0101 shows that there was significant oral mucositis scores between post test scores in both experimental and control groups. Applications of pure honey was effective. Conclusion: The findings of the study concluded that, the application of pure honey was effective on radiation-induced mucositis in cancer patients undergoing radiotherapy and the level of mucositis is decreasing.