Background: Retinal vein occlusion is second commonest retinal vasculopathy. Narrow optic nerve diameter is a risk factor. A variation in ventricular ejection fraction can alter pressure inside any blood vessel. Purpose: To study ejection fraction in all cases of Retinal Vein Occlusion Methods: Prospective nonrandomised cohort study since 1997 to 2012.Standard protocol was followed in all cases of RVO.A/B Scan and echocardiography was done to assess optic nerve diameter and ejection fraction respectively. Equal number of matched controls was registered. Results: 82 cases of RVO, mean age 48.5, male preponderance in below 40 years. Variable ejection between preserved (pEF__ampersandsigngt;50%) and reduced (rEF__ampersandsignlt;50%) was significantly associated with RVO. Multivariate regression analysis shows RVO__ampersandsignrsquo;s significant association between narrower optic nerve diameter, shorter axial length and variable ejection fraction Conclusion: Variable Ejection fraction is a risk factor in RVO.