Introduction: Ayurvedic medications are extensively used across the world for illness prevention and treatment. The components found in the Coroprotect tablet are Ashwagandha ext., Suddhashilajit ext., Giloyext., Dadim ext., Haridra ext., Saragavo ext., Brahmi ext., Papaya ext., Methiext., Punarnava ext., Kalmegh ext. etc. all are found to be safe and used in Ayurvedic system for many years. Objective: In Rodents, acute and subacute toxicity of coroprotect tablet was studied after a single and repeated 28-day oral dosage administration. Method: In acute toxicity testing, 2000 mg/kg single dose of coroprotect tablet have been employed, whereas doses of 100, 200, and 400mg/kg have been utilized in subacute toxicity testing over a 28-day period in rodents. Result: With coroprotect tablet administration, no treatment-related fatalities or toxic signs have been identified in an acute toxicity investigation. There have been no significant variations in body weight changes, water/food intake, haematology, or clinical biochemistry content among the control and coroprotect tablet groups in the repeated dosage research. Between the control and coroprotect pill groups, no gross pathological abnormalities or differences in relative organ weights were found. With coroprotect tablet therapy, the histopathological investigation indicated no abnormalities. Conclusion: In a repeated dosage toxicity study in rodents, the coroprotect tablet was determined to be safe at all dose levels.