Introduction: Due to advancements in medical services, life span of individuals has increased. Increased age also increases neurodegenerative problems generally in the geriatric population. Neurodegenerative disorders affect many individuals across the world by increasing their disability. Aim: Aim of the study was to evaluate undiagnosed neurodegenerative disorders in detail to understand and gain insight into the selected case. Case Report: Here reported case is affected by undiagnosed neurodegenerative syndrome at the early age of 34 years. The patient was also invited by the National Institute of Health, US under the Undiagnosed Program for further investigations. The patient was managed by a combined approach of allopathy, physiotherapy and naturotherapy. Discussion: The patient was also suspected for diagnosis of Bipyramidal syndrome, Stiff man syndrome, Motor Neuron Disease, Neimann pick disease type C, Krebbee__ampersandsignrsquo;s disease, Chediak Higashi disease affecting the central nervous system by Neuro physician. The patient represents a rarest of rare case of an Undiagnosed Neurodegenerative Program. Conclusion: The patient can be benefited in symptoms by a combined approach of medicine and physiotherapy in case of undiagnosed neurodegenerative.