Introduction: Transvaginal Sonography has emerged as an important modality in investigating AUB, but it cannot diagnose endometrial pathology in absence of histopathology of the endometrium. The addition of Color doppler (CDTU) to TVS can help in diagnosis by evaluation of blood flow through vascular patterns and Uterine artery indices. Objective: To evaluate the role of Transvaginal Ultrasonography and Colour Doppler (CDTU) in abnormal uterine bleeding and correlate them with histopathological diagnosis. Methods: TVS and Colour Doppler were performed in 70 patients with AUB. TVS included evaluation of endometrium, size of the uterus, any uterine or adnexal pathology. The vascular pattern of Spiral arteries of the endometrium and uterine arteries was analyzed. Uterine artery indices (RI and PI) were calculated. 1.83 was taken as cut-off for PI and 0.81 was taken as cut-off for RI. The results were then compared with histopathology of the endometrium. Results: On TVS, the causes of AUB were Leiomyoma in 17.1%, polyp in 10%, PCOS in 8.5%, Adenomyosis in 5.7%, and Endometrial growth in 2.8%. 11 patients had suspected malignancy by uterine indices of RI (__ampersandsignlt;0.81) and PI (__ampersandsignlt;1.83) of a uterine artery by CDTU. Specificity and Sensitivity of TVS with CDTU for AUB M was 100% and 90.77% respectively. The positive predictive value was 45.45% and the negative predictive value was 100%. Conclusion: Colour Doppler of the uterine artery and endometrial spiral arteries with vascular impedance, improves the diagnostic accuracy of TVS for the prediction of endometrial pathologies and facilitates in screening for malignant and premalignant lesions.