Introduction: Distal radius fracture (DRF) is a common injury that can happen to anyone. Cast treatment, with or without closed reduction, has long been considered a viable alternative for DRF treatment. Aim: The purpose of the study was to assess how low-profile plates treat unstable and intra-articular distal radial fracture (DRF) in terms of clinical, functional, and radiological outcomes. Methodology: This study comprised 40 distal radius fractures treated with fragment selective fracture therapy because they were unstable and intraarticular. The Mayo wrist score was used to assess wrist function and reported postoperative problems. The researchers were looking for people over the age of 20, with closed unstable distal radius fractures, and closed intraarticular distal radius fractures. A longitudinal study. This study was conducted at, Dow University __ampersandsignamp; Dr Ruth K.M.Pfau Civil Hospital Karachi Pakistan from March 2020 to March 2021. Results: The participants__ampersandsignrsquo; ages ranged from 20 to 60, with a median age of 37 years. Fractures were most common in people between the ages of 42 and 50 years. In this study, there were n=23 (57.5%) male patients and n=17 (42.5%) female patients. The right side fracture was present in n=28 (70%) patients and in n=12 (30%) patients on the left side. The Mayo scoring system was used to analyze the results. Out of forty patients, twenty-one patients had outstanding results, ten had reasonable results, and nine had acceptable results. Conclusion: Low-profile plates improve clinical and functional outcomes in the treatment of intra-articular DRF by providing secure fixation, allowing early joint mobilization, and improving all above outcomes.