Introduction: Osteoarthritis is a disorder of the diarthrodial joint, a slow degenerative disease clinically characterized by pain, loss of range of motion. On x-ray seen as reduced joint space, formation of osteophytes and deformity. Manual therapy has been proved to be an effective treatment method in knee osteoarthritis (OA), but there is a need to investigate the effectiveness of MIMG manual therapy technique. There is limited evidence on the effect of MIMG protocol in knee OA. Aim: To find the effectiveness of MIMG protocol on pain and range of motion in knee osteoarthritis. Methodology- 38 subjects with the diagnosis of knee OA stage II and III on Kellegren Lawrence classification were recruited from Shree K.K. Sheth physiotherapy Centre, Rajkot, Gujarat. An interventional study was conducted on 38 subjects. Result: The outcome measures MIMG protocol is effective as conventional exercises in treating OA knee. Conclusion: MIMG can be suggested as one of the treatment protocols.