Introduction: Paraphenylenediamine is a low-cost and readily available hair dye in Pakistan. It is highly toxic and lethal substance when ingested. This study was conducted to determine the frequency of hyperkalemia in patients with PPD poisoning. Objective: To determine the frequency of hyperkalemia in patients with PPD-poisoning at a tertiary care hospital. Material and Methods: A descriptive case series study was conducted at Teaching Hospital Dera Ghazi Khan, from 1st January, 2019 to 30th June, 2020. A total of 87 patients fulfilling the inclusion criteria were enrolled. After the approval from hospital ethical Committee, informed consent was obtained from all the patients. Once registered, 3 ml venous blood sample was drawn and sent to the hospital laboratory (after every 12 hours) for serum potassium levels to diagnose hyperkalemia. Data was entered and analyzed using SPSS-23. Results: Out of 87 cases, 20 (23.0 %) were male while 67 (77.0 %) were female patients. Mean age was25.69 __ampersandsignplusmn; 7.43 years with age range of 18-45 years. 65 patients (74.7 %) belonged to rural areas and 22 (25.3 %) to urban areas. Poor socioeconomic status was noted in 71 (81.6%) while 16 (18.4%) were of middle income. Out of 87 cases, 52 (58.9%) were illiterate and 35 (40.2%) were literate. Reason for intake was homicidal in 22 (25.3%) and suicidal in 65 (74.7%). Mean hospital stay was 6.23 __ampersandsignplusmn; 3.39 days and 54 (62.1 %) had hospital stay for more than 3 days. Mean serum potassium level was 5.10 __ampersandsignplusmn; 0.45 mmol/L and hyperkalemia was noted in 23cases (26.4%). Conclusion: High frequency of hyperkalemia was noted in our study among patients with Paraphenylenediamine poisoning and resulted in prolong duration of hospitalization.