Introduction: Metabolic syndrome is constituted by hyperlipidemia with presentation of diverse lipid profile including hypertriglyceridemia, hypercholesterolemia and hereditary combined hyperlipidemia. Objectives: To find the synergistic effect Cinnamomum cassia and apple cider vinegar on combined administration in albino mice. Methodology: This was an experimental study and conducted at Department of Pharmacology, Al-Nafees Medical College and Hospital Islamabad in collaboration with Animal House of the National Institute of Health, Islamabad-Pakistan. A total of 50 adult albino mice were randomly divided into 5 groups. Hyperlipidemia was induced during the first two weeks of experimentation, and this was followed by treatment period of 6 weeks. Groups were categorized as A (Normal Control), B (Treated Control), C (Treatment Group I), D (Treatment Group II), and E (Treatment Group III). Diet pattern for these groups remained to be high cholesterol, Simvastatin 0.6 mg/Kg BW, ACV upto 15% of animal feed, Cinnamon powder 6mg/Kg BW and Cinnamon with high cholesterol diet respectively. Blood samples to estimate parameters of lipid profile were collected at 0,15th, 30th, 45th and 60th days. Results: A significant decrease (p__ampersandsignlt;0.05) was observed in total cholesterol, triglyceride and low-density lipoprotein at 45th and 60th days as compared to normal control group. Serum high-density lipoprotein was low at 15th day among all groups because of induction of hypercholesterolemia, which was then noted to be reversed at 60th day. Highest surge was noted to be in group E and significant increase in all groups (p__ampersandsignlt;0.05) was noted in all groups as compared to normal control. Conclusion: Apple Cider Vinegar keeps the anti-hyperlipidemia effect which was found to be significantly high (p__ampersandsignlt;0.05) in combination with Cinnamomum cassia when consumed by male albino mice.