The microsponge delivery system is a profoundly cross-connected permeable, polymeric microsphere, polymeric system comprising of permeable microspheres that can capture and delivery them into the skin throughout a significant stretch of time. This system furnishes broadened discharge with diminish disturbance, better resistance, worked on warm, physical and compound steadiness. The principal objective of any prescription transport structure is to achieve needed gathering of the medicine in blood or tissue, which is therapeutically incredible and non-noxious for a somewhat long period in this review different strategy for planning of microsponge drug delivery system are considered. Different benefits are likewise given which shows the significance of this strategy for the delivery of medication over the other medication delivery system. An ever increasing number of advancements in delivery system are being coordinated to enhance the adequacy and cost viability of the treatment. Microsponge innovation offer entanglement of fixing and is accepted to contribute towards lessen incidental effects, further developed strength, expanded style, and improved plan adaptability. Furthermore various examinations have affirmed that microsponge systems are not bothering, non-mutagenic, non-allergenic and non-harmful Microsponge delivery innovation is being utilized at present in beauty care products, over the counter, healthy skin, and sunscreen and remedy items.