Introduction: Physical exercise has been identified as a potential intervention to improve quality of life in women with breast cancer receiving chemotherapy. Fatigue is the most common side effect of breast cancer treatment with chemotherapy, selected biologic response modifiers. Aim: To assess the effect of aerobic exercises on fatigue among breast cancer patients receiving chemotherapy in selected hospitals. Method: Quasi__ampersandsignndash;experimental with pre-test post-test control group design was adapted. The study was conducted among breast cancer patients receiving chemotherapy.60 samples were selected using non-probability purposive sampling and data collection was done using demographic variables, Clinical Profile, and Modified Fatigue Assessment Scale. The interventional group received an aerobic exercise programme with low to moderate intensity, two times a day, lasting for 20 minutes for 2 weeks. Results: Aerobic exercises were significantly effective in reducing the level of fatigue among experimental breast cancer patients receiving chemotherapy. Conclusion: This study concludes that an aerobic exercise program of precisely defined intensity, duration, and frequency can be prescribed as therapy for primary fatigue in breast cancer patients.