Introduction: Indian traditional system of medicine has huge varieties of various medicinal plants with pharmacological importance. __ampersandsignldquo;Archeologically__ampersandsignrdquo; plants have played a significant part in medicine across the world. Aim: The present study aims to open new avenues for the improvement of medicinal uses of the taken medicinal plant Coccinia indica. Methodology: In this study, the ethanolic extracts of leaf (ELECI) and fruit (EFECI) of Coccinia indica have been taken to evaluate the anti-diabetic and anti-inflammatory activity. Results: The outcome obtained shows that the extracts possessed significant level of in-vitro anti-diabetic activity by inhibition of glycosylation of haemoglobin, glucose transport across yeast cells and __ampersandsignalpha;-amylase inhibition. In this, inhibition of glycosylation __ampersandsignamp; __ampersandsignalpha;-amylase was a dose dependent manner and glucose transport differs with the sample. The concentration of the glucose that remains in the medium confirms the taken plant possess significant anti-diabetic activity. Conclusion: The study also concluded that the taken plants should possess anti-inflammatory activity through increase membrane stability of lysosome cell that has equal physiological properties with erythrocytes membrane cell and it has no hemolytic activity. However, these effects should be confirmed using in-vivo models and clinical trials for its effective utilization as therapeutic agents.