From long back herbal drugs are used for treatment of arthritis and other joint disorders which require potent analgesic and anti-inflammatory action together with pharmacological activities which can induce the remission by modifying the course of the disease. Our ancient text of Ayurveda like Charak Samhita, Charak Sutrasthan, Sushrut Sutrasthan, Bhavprakash, Rajnighantu prescribe the use of different Herbo-mineral agents in such diseased conditions, which gives a vision to different researcher to investigate the plant component and their pharmacological action for their therapeutic use. The present work is focused on the development of new polyherbal anti-arthritic formulation by carefully selecting few herbs for treatment of arthritis, which may full fill the criteria of Herbal combination therapy i.e. provide synergistic action without any interaction so that less dose may be required and different organ or system affected by the disease can be targeted with focus on joint inflammation and pain. To achieve this objective four drugs were selected, which were already reported for their potent anti-rheumatic and anti-inflammatory activity i.e. Guggal, Sunth, Arand, Giloe and two diuretic drugs i.e. Gokhru and Punarnava are added in the formulations, which helps in treatment of associated disorders. The combination suitability was derived from the Ancient literature consulting Ayruvedic physicians. Finally the tablet dosage form was prepared from a developed Polyherbal formulation. Four different batches are prepared by changing the binder in tablet formulation and evaluated for standard quality parameters for the tablet.