Pharmacovigilance is also often understood as Drug Safety. For drug safety, Adverse Drug Reaction (ADR) must be monitored throughout the life of the drug, from its development, clinical trials, and post-approval. The discipline of Pharmacovigilance has gained its due importance in India recently in the last 10 to 15 years. The importance of pharmacovigilance increases even more in the pandemic situation. Numerous drugs are being used empirically according to experience and availability to treat Covid-19. The pandemic is an insight to regulate the highly unregulated drug distribution system. The system can be strengthened by training of human resource, public-private partnerships, legislation, communication, research and innovation Pharmacovigilance has witnessed substantial development over the years, yet there is a need for a practical revolutionary roadmap to tackle all the hindrances to fortify its symphonic functioning. The public confidence around the efficiency of Pharmacovigilance will build when people have access to good-quality and safe medicines and a suitable system for the distribution of medicines that have cleared Pharmacovigilance.