Introduction: Impacted mandibular third molars are one of the most common findings in the field of dentistry which requires surgical removal. Local Anaesthetics plays a major role to perform the procedure pain-free although the anesthetics may exhibit some haemodynamic changes. Aim: This study aimed to assess and compare the hemodynamic changes during the surgical removal of lower bilateral impacted third molars using local anaesthetic agents 2% Lidocaine or 4%Articaine both in conjunction with 1:100000 epinephrine concentration. Methodology: Forty-one patients with a mean age of 32.6 were enrolled to bilateral surgical removal of lower impacted third molars with an interval of three to four weeks between each surgery. Clinical parameters like Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure, Peripheral Saturation of Oxygen, Temperature and calculated parameters like Rate Pressure Product and Pressure Rate Quotient were assessed at three different time points: baselilne (Pre-operatively), Osteotomy/Odontosection/Luxation (Intra-operatively) and five minutes after completion of suture (Post-operatively). Result: Forty-one patients underwent thorough clinical examination, among which 33 patients fulfilled the criteria as they participated in both the surgical procedures. The present study found significant difference in the haemodynamic changes when comparing between the three-time intervals in each group during the surgical procedure Conclusion: No significant differences were found when comparing the hemodynamic behavior between both the groups (2% lidocaine and 4% articaine) although significant differences were noted when comparing between the time points within each group.