Introduction: Rheumatoid Arthritis (RA) is a joint-damaging chronic inflammatory disease that affects the synovium and articular cartilage. RA is characterized by symmetric arthritis that primarily affects the tiny joints of the hands and feet. Adipokines play a role in the etiology of a variety of metabolic, vascular, and inflammatory diseases. The goal of this study is to compare the levels of inflammatory adipocytokines (chemerin and visfatin) and their ratios, as well as certain related biomarkers, in RA patients and healthy controls to see if they can help diagnose Rheumatoid Arthritis. Methods: A total of 70 (25 males and 45 females) RA patients__ampersandsignrsquo; group with ages ranging from 45-65 years and 30 (10 males and 20 females) as the control group with ages ranging from 40-70 years old were involved in the study. All individuals had their biochemical parameters, demographic profile and serum chemerin and visfatin concentrations analyzed. Results: Our findings indicated that serum levels of Visfatin and Chemerin were significantly higher in individuals with rheumatoid arthritis than in healthy controls. Chemerin had moderate positive correlations with C-reactive protein (CRP) and total cholesterol (TC) while, it had weak negative correlation with high-density lipoprotein cholesterol (HDL). Conclusion: The variations in adipokine levels that we observed could play a role in diagnose of Rheumatoid Arthritis.