Introduction: Pharmacotherapy is an important part of maintaining one__ampersandsignrsquo;s health. Medications are used to manage symptoms, control disease progression, and prevent new diseases in many situations. Drug usage studies have proved extremely useful in determining the effects of medications and prescribing patterns on healthcare. They are essential for using evidence-based medicine and making healthcare decisions. Aim: To assess the prevalence of patient complaints and drug prescriptions in the orthopedics Study Design: Cross-sectional Study Place and Duration: Bolan Medical complex Hospital Quetta Balochistan, Pakistan from June 2019 to June 2020 Methodology: Patients aged 12 to 80 years old who visited the orthopedic department were included with convenience sampling strategy. Prescriptions of 377 patients were evaluated. Data was collected on a predesigned form downloaded from the WHO website. Pharma Guide was used to assess the generic names of the prescribed drugs. SPSS version 20 was used for descriptive analysis. Results: The results showed a higher number of males, 61.53% (n=232), and in the age group of 61 and above. Lower back pain was reported in 165 (43.76 %) of the patients. Total 95 (25.19%) patients came due to fractures. A total of 377 prescriptions were written, with 1925 medications being prescribed. This equates to an average of 5.10 pills per patient. Analgesics, Gastroprotective medicines and Antibiotics were prescribed in 751 (39.01%), 394 (20.46%) and 371 (19.27%) prescriptions, respectively. Conclusion: Multidrug prescription is very common. Analgesics, stomach acid inhibitors, and antimicrobials are commonly used in orthopedic outpatient department (OPD).