Introduction: Ankylosing spondylitis is one of the challenging disorders when it comes to managing with surgical treatment. The modified New York criteria include axial lumber pain greater than 3 months which may be reduced by exercise but not by bed rest. Concerning the spinal involvement ankylosing spondylitis ascending inflammation and calcifies the ligamentous insertion points, facet joints, and the annulus fibrosis. Objectives: To evaluate the patient__ampersandsignrsquo;s characteristics, diagnostic criteria and complications of surgical treatment of spinal injuries in patients with ankylosing spondylitis. Study Design: Retrospective Study Place and Duration: This study was conducted in People__ampersandsignrsquo;s University of Medical and Health Sciences for women Nawabshah, Pakistan from January 2019 to December 2020 Methodology: We used the impairment scale of the American Spinal Injury Association (ASIA) for analyzing clinical outcomes. Furthermore, British Medical Research Council (BMRC) grading system was also used to analyze the patient__ampersandsignrsquo;s outcomes. We recorded trauma time, diagnosis time, and surgical intervention for analyzing the results. Patient characteristics and outcomes were also reported. For analyzing the fractures related parameters we performed CT and MRI scanning of all patients before surgery. Results: In this study, we recruited 60 patients diagnosed with fractures of the cervical, thoracic, and lumbar spine. A total of 18.3% patients reported surgical complications whereas surgical revision was required in 13.3% cases. Postoperative pneumonia, pulmonary decompensation, and cardiac decompensation were observed in 38.3%, 25%, and 20% of patients respectively. Conclusion: Our study concluded that ankylosing spondylitis patients having cervical spine fractures required special treatment. These patients are more prone to spinal injury even after trivial trauma. Comorbidities and advanced age increase the complications ratio and even result in death.