Introduction: Hormones are primary messengers that regulate the physiological and behavioral aspects of the body. Bone, a dynamic connective tissue, forms the framework of the body alongside its contribution in maintaining homeostasis and hosting the bone marrow. Disturbances in hormonal levels disrupt bone health thereby leading to impaired quality of life. Aim: To encapsulate the effects of various endocrine disorders on bone mineral density based on previous clinical studies. Methodology: An electronic search was conducted across PubMed, EMBASE, CINAHL, Google Scholar and Cochrane databases during the period of March to July 2021 by two reviewers independently using Medical Subject Headings (MeSH) terms. Result: The search yielded a total of 208 articles and further screening based on selection criteria resulted in inclusion of 19 studies to elicit the effects of commonly prevalent endocrine disorders on bone mineral density. Studies revealed that most hormonal imbalances have a negative impact on the bone mineral density (BMD) at varying degrees. Conclusion: Endocrine disorders have become highly prevalent at present deteriorating the life standards, especially the middle-aged and elderly population. Any disruption in this normality will lead to altered bone mineral density and further risks of fracture or immobility. Constant monitoring of hormonal levels and bone health is required to enhance the quality of living alongside an increased life expectancy.