Leishmaniases are parasitic diseases caused by Leishmania species and transmitted by the phlebotomine sandflies. In Morocco, Leishmaniases are a major public health problem with two clinical forms: cutaneous and visceral Leishmaniasis. Khemisset Province is one of the Moroccan regions where cases of both cutaneous and visceral Leishmaniasis were reported without official data about epidemiological status. Epidemiological and entomological investigations were conducted in Khemisset Province based on 20-year epidemiological data (1997-2016). The results showed the presence of both clinical forms of Leishmaniasis in the study area. All ages and both genders were affected by these different forms of the disease. Five sandfly species were identified morphologically in the study area with the dominance of Phlebotomus sergenti (61.11%). The Province of Khemisset should be regarded as a potential focus for Leishmaniasis in the region because of the presence of all the components of the disease transmission cycles. It is suggested that the competent authorities monitor the Khemisset area constantly to prevent the danger and spread of this epidemic.