Introduction: It is known that actual values of thickness of epidermis of the skin and its variations with body site, age and sex are important in fields of medical and biological research. The variations in skin reaction to certain stimuli could be due to biological factors such as epidermal thickness, dermal thickness, distribution of epidermal appendages etc. Aims: Aim of the present study was to establish variations in the number of different components of skin in human cadavers. Material and Methods: Skin was procured from the sole of six freshly formalin-fixed human cadavers. Out of these three were males and three were females. The age of male and female cadavers ranged between 60 to 70years (mean age 67years). Skin samples measuring 1cm (L) X 0.5cm (B) were taken from the centre of the sole. Tissue was preserved in 10% formaldehyde for 48 hours and further histological techniques were followed. Results: In females thickness of the epidermis (Edp) of were observed (866.07__ampersandsignplusmn;22.20__ampersandsignmicro;m), the thickness of stratum corneum (470.43__ampersandsignplusmn;21.68__ampersandsignmicro;m), layers of stratum spinosum and stratum granulosum were 3, number of rete pegs (11.41__ampersandsignplusmn;1.01), depth of rete pegs (62.89__ampersandsignplusmn;5.96__ampersandsignmicro;m), the thickness of the papillary dermis and reticular dermis were(182.23__ampersandsignplusmn;14.60__ampersandsignmicro;m) and (871.20__ampersandsignplusmn;16.93__ampersandsignmicro;m) respectively. Whereas In males thickness of the epidermis(Edp) were observed (562.10__ampersandsignplusmn;24.91__ampersandsignmicro;m), the thickness of stratum corneum was (484.36__ampersandsignplusmn;49.21__ampersandsignmicro;m), layers of stratum spinosum and stratum granulosum were 3 and 1 respectively, the number of rete pegs 10.81__ampersandsignplusmn;1.92, depth of rete pegs (103.04__ampersandsignplusmn;18.95__ampersandsignmicro;m), thicknesses of the papillary dermis and reticular dermis was (100.10__ampersandsignplusmn;21.68__ampersandsignmicro;m) and (829.76__ampersandsignplusmn;186.50__ampersandsignmicro;m) respectively. Conclusion: Females showed thicker epidermis as well as dermis in comparison to males. Females had more number rete pegs but these are shallower than males.